Misplaced Pages

Germacrene A hydroxylase (EC 1.14.13.123) is an enzyme with systematic name (+)-germacrene-A,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme catalyses the following chemical reaction

(+)-germacrene A + NADPH + H + O₂ ${\displaystyle \rightleftharpoons }$ germacra-1(10),4,11(13)-trien-12-ol + NADP + H₂O

Germacrene A hydroxylase is a heme-thiolate protein (P-450).

References

1. de Kraker JW, Franssen MC, Dalm MC, de Groot A, Bouwmeester HJ (April 2001). "Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis". Plant Physiology. 125 (4): 1930–40. doi:10.1104/pp.125.4.1930. PMC 88848. PMID 11299372.
2. Nguyen DT, Göpfert JC, Ikezawa N, Macnevin G, Kathiresan M, Conrad J, Spring O, Ro DK (May 2010). "Biochemical conservation and evolution of germacrene A oxidase in asteraceae". The Journal of Biological Chemistry. 285 (22): 16588–98. doi:10.1074/jbc.M110.111757. PMC 2878029. PMID 20351109.

External links

• Germacrene+A+hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• v
• t
• e

• EC 1.14.13
• EC 1.14.13 stubs