Gerontogens are environmental agents that can accelerate aging in some animals, including humans. Gerontogens are typically toxic chemical agents, such as those found in cigarette smoke. However, many other things can act as gerontogens, including ultraviolet radiation, chemotherapy treatment, and arsenic.
Gerontogens work in two different ways. They can shorten telomeres, repetitive nucleotide sequences at the end of chromosomes, which accelerates cell destruction. Gerontogens can also accelerate the rate of cellular senescence, where normal diploid cells cease to divide. This can be measured using the body's levels of the protein p16.
References
- "Toxins in the Environment Further Age Humanity". Retrieved 2015-10-01.
- "Scientists Urge Study of Environmental Factors That May Speed Aging". News.nationalgeographic.com. Archived from the original on May 30, 2014. Retrieved September 30, 2015.
- "Toxins in the environment might make you older than your years". Eurekalert.org. Retrieved September 30, 2015.
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