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CCDC88A
Identifiers
Aliases	CCDC88A, APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, coiled-coil domain containing 88A, PEHO, PEHOL
External IDs	OMIM: 609736; MGI: 1925177; HomoloGene: 41180; GeneCards: CCDC88A; OMA:CCDC88A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p16.1 Start 55,287,842 bp End 55,419,895 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A3.3 Start 29,323,658 bp End 29,460,808 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus corpus callosum ventricular zone ganglionic eminence Achilles tendon subthalamic nucleus buccal mucosa cell inferior ganglion of vagus nerve tendon of biceps brachii testicle Top expressed in Rostral migratory stream barrel cortex tail of embryo genital tubercle lateral septal nucleus lateral geniculate nucleus mammillary body ventromedial nucleus spermatid anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity phosphatidylinositol binding actin binding microtubule binding protein kinase B binding dynein light intermediate chain binding G-protein gamma-subunit binding Cellular component cytoplasm Golgi apparatus cell projection endoplasmic reticulum lamellipodium membrane cytoplasmic vesicle cytosol plasma membrane cell leading edge centrosome centriole cytoskeleton ciliary basal body COPI-coated Golgi to ER transport vesicle Biological process regulation of actin cytoskeleton organization nervous system development DNA replication membrane organization cell migration lamellipodium assembly activation of protein kinase B activity regulation of DNA replication TOR signaling regulation of protein phosphorylation regulation of cell population proliferation regulation of neuron projection development cell projection organization cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization positive regulation of cilium assembly positive regulation of protein localization to cilium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55704 108686 Ensembl ENSG00000115355 ENSMUSG00000032740 UniProt Q3V6T2 Q5SNZ0 RefSeq (mRNA) NM_001135597 NM_001254943 NM_018084 NM_001365480 NM_176841 NM_001363368 NM_001363369 RefSeq (protein) NP_001129069 NP_001241872 NP_060554 NP_001352409 NP_789811 NP_001350297 NP_001350298 Location (UCSC) Chr 2: 55.29 – 55.42 Mb Chr 11: 29.32 – 29.46 Mb PubMed search
Wikidata
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Girdin is a protein that in humans is encoded by the CCDC88A gene. Although its cellular function are not fully elucidated, it has been associated with glioma.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000115355 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032740 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem. 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.
6. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem. 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.
7. "Entrez Gene: KIAA1212 KIAA1212".
8. Gu, F.; Wang, L.; He, J.; Liu, X.; Zhang, H.; Li, W.; Fu, L.; Ma, Y. (2014). "Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells". Journal of Neurochemistry. 131 (4): 457–469. doi:10.1111/jnc.12831. PMID 25060559. S2CID 206090300.

External links

• DISC1 Players Gird For Adult Neurodevelopment - Schizophrenia Research Forum, 8 oct 2009
• Human CCDC88A genome location and CCDC88A gene details page in the UCSC Genome Browser.

Further reading

• Kitamura T, Asai N, Enomoto A, et al. (2008). "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin". Nat. Cell Biol. 10 (3): 329–37. doi:10.1038/ncb1695. PMID 18264090. S2CID 23157573.
• Enomoto A, Murakami H, Asai N, et al. (2005). "Akt/PKB regulates actin organization and cell motility via Girdin/APE". Dev. Cell. 9 (3): 389–402. doi:10.1016/j.devcel.2005.08.001. PMID 16139227.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.

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