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In enzymology, a globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.79) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (11)-ceramide ${\displaystyle \rightleftharpoons }$ UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)- beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide

The 3 substrates of this enzyme are UDP-N-acetyl-D-galactosamine, ], and (11)-ceramide, whereas its 3 products are UDP, ], and ].

Wrongly characterized previously as globotriosylceramide beta-1,6-N-acetylgalactosaminyl-transferase (EC 2.4.1.154

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galact osyl-(1->4)-beta-D-glucosyl-(11)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase. This enzyme participates in glycosphingolipid biosynthesis - globoseries and glycan structures - biosynthesis 2.

References

1. Lockney MW, Sweeley CC (August 1982). "Characterization of a glycosphingolipid beta-N-acetylgalactosaminyl-transferase activity in cultured hamster (nil) cells". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 712 (2): 234–41. doi:10.1016/0005-2760(82)90339-3. PMID 6812637.

• Chien JL, Williams T, Basu S (1973). "Biosynthesis of a globoside-type glycosphingolipid by a -N-acetylgalactosaminyltransferase from embryonic chicken brain". J. Biol. Chem. 248 (5): 1778–85. PMID 4632917.
• Ishibashi T, Kijimoto S, Makita A (1974). "Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney". Biochim. Biophys. Acta. 337 (1): 92–106. doi:10.1016/0005-2760(74)90043-5. PMID 4433547.
• Taniguchi N, Makita A (1984). "Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen". J. Biol. Chem. 259 (9): 5637–42. PMID 6425294.
• Urano T, Furukawa K (2000). "Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase". J. Biol. Chem. 275 (51): 40498–503. doi:10.1074/jbc.M006902200. PMID 10993897.

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