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In enzymology, a glutamate—ethylamine ligase (EC 6.3.1.6) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + ethylamine ${\displaystyle \rightleftharpoons }$ ADP + phosphate + N₅-ethyl-L-glutamine

The 3 substrates of this enzyme are ATP, L-glutamate, and ethylamine, whereas its 3 products are ADP, phosphate, and N5-ethyl-L-glutamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-glutamate:ethylamine ligase (ADP-forming). Other names in common use include N5-ethyl-L-glutamine synthetase, theanine synthetase, and N5-ethylglutamine synthetase.

References

• Sasaoka K; Kito M (1964). "Synthesis of theanine by tea seedling homogenate". Agric. Biol. Chem. 28 (5): 313–317. doi:10.1271/bbb1961.28.313.
• Sasaoka K, Kito M, Inagaki H (1963). "Studies on the biosynthesis of theanine in tea seedlings. Synthesis of theanine by the homogenate of tea seedlings". Agric. Biol. Chem. 27: 467–468. doi:10.1271/bbb1961.27.467.
• Sasaoka K, Kito M, Onishi Y (1965). "Some properties of the theanine synthesizing enzyme in tea seedlings". Agric. Biol. Chem. 29 (11): 984–988. doi:10.1271/bbb1961.29.984.

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