Glycoprotein endo-alpha-1,2-mannosidase

Glycoprotein endo-α-1,2-mannosidase (EC 3.2.1.130, glucosylmannosidase, endo-α-D-mannosidase, endo-α-mannosidase, endomannosidase, glucosyl mannosidase) is an enzyme with systematic name glycoprotein glucosylmannohydrolase. It catalyses the hydrolysis of the terminal α-D-glucosyl-(1,3)-D-mannosyl unit from the GlcMan₉(GlcNAc)₂ oligosaccharide component of the glycoprotein produced in the Golgi membrane.

This protein is involved in the synthesis of glycoproteins.

References

Lubas WA, Spiro RG (March 1987). "Golgi endo-α-D-mannosidase from rat liver, a novel N-linked carbohydrate unit processing enzyme". The Journal of Biological Chemistry. 262 (8): 3775–81. PMID 3818665.
Tulsiani DR, Coleman VD, Touster O (February 1990). "Asparagine-linked glycoprotein biosynthesis in rat brain: identification of glucosidase I, glucosidase II, and endomannosidase (glucosyl mannosidase)". Archives of Biochemistry and Biophysics. 277 (1): 114–21. doi:10.1016/0003-9861(90)90558-g. PMID 2407194.

External links

Glycoprotein+endo-alpha-1,2-mannosidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase
Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme
Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Klotho Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 3.2.1

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