Griffis or Griffiss is a surname. Notable people with the surname include:
- Elliot Griffis, composer
- William Elliot Griffis, orientalist
- Rhoda Griffis (born 1965), American actress
- Townsend Griffiss, aviator
See also
- 16253 Griffis, asteroid
- Griffiss International Airport, in Rome, New York
- Griffis Sculpture Park, in Cattaraugus County, New York
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