Grimace may refer to:
- A type of facial expression usually of disgust, disapproval, or pain
- Grimace (composer), a French composer active in the mid-to-late 14th century
- Grimace (character), a McDonaldland marketing character developed to promote the restaurant's milkshakes
- Grimace scale, a method of assessing the occurrence or severity of pain
- Grimace Shake, a McDonald's milkshake
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