HFI may refer to:
Businesses and organisations
- Hereditary fructose intolerance, a metabolic deficiency
- HFI Flooring Inc, a Canadian company
- Hamfest India, an amateur radio convention
- Handball Federation of India
- Holy Family Institute
Government
- Healthy Forests Initiative, a US federal law
- Horizontal fiscal imbalance, in macroeconomics
- Human Freedom Index, in human rights
Other uses
- High Frequency Instrument, aboard the Planck spacecraft
- Human factors integration, in engineering
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