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HIST3H2A

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Protein-coding gene in the species Homo sapiens
H2AW
Identifiers
AliasesH2AW, histone cluster 3 H2A, HIST3H2A, H2A.W histone
External IDsOMIM: 615015; MGI: 2448458; HomoloGene: 137357; GeneCards: H2AW; OMA:H2AW - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for H2AWGenomic location for H2AW
Band1q42.13Start228,434,777 bp
End228,457,873 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for H2AWGenomic location for H2AW
Band11|11 B1.3Start58,845,511 bp
End58,847,656 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • testicle

  • ganglionic eminence

  • left adrenal cortex

  • apex of heart

  • right adrenal gland

  • right adrenal cortex

  • gonad

  • ventricular zone
Top expressed in
  • spermatocyte

  • retinal pigment epithelium

  • neural layer of retina

  • medial ganglionic eminence

  • lens

  • epithelium of lens

  • external carotid artery

  • ciliary body

  • olfactory bulb

  • trigeminal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

92815

319162

Ensembl

ENSG00000181218
ENSG00000284841

ENSMUSG00000078851

UniProt

Q7L7L0

Q8BFU2

RefSeq (mRNA)

NM_033445

NM_178218

RefSeq (protein)

NP_254280

NP_835736

Location (UCSC)Chr 1: 228.43 – 228.46 MbChr 11: 58.85 – 58.85 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A type 3 is a protein that in humans is encoded by the HIST3H2A gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.

References

  1. ^ ENSG00000284841 GRCh38: Ensembl release 89: ENSG00000181218, ENSG00000284841 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000078851 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. ^ "Entrez Gene: HIST3H2A histone cluster 3, H2a".

Further reading

PDB gallery
  • 1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT 1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
  • 1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION 1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
  • 1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE 1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE
  • 1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution 1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution
  • 1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution 1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution
  • 1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution 1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution
  • 1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
  • 1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
  • 1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
  • 1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1s32: Molecular Recognition of the Nucleosomal 'Supergroove' 1s32: Molecular Recognition of the Nucleosomal 'Supergroove'
  • 1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution 1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution
  • 1zbb: Structure of the 4_601_167 Tetranucleosome 1zbb: Structure of the 4_601_167 Tetranucleosome
  • 1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core 1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core
  • 2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione 2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione
  • 2cv5: Crystal structure of human nucleosome core particle 2cv5: Crystal structure of human nucleosome core particle
  • 2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes 2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes
  • 2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element 2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element
  • 2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN 2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN
  • 2nzd: Nucleosome core particle containing 145 bp of DNA 2nzd: Nucleosome core particle containing 145 bp of DNA


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