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AGFG2
Identifiers
Aliases	AGFG2, HRBL, RABR, ArfGAP with FG repeats 2
External IDs	OMIM: 604019; MGI: 2443267; HomoloGene: 4430; GeneCards: AGFG2; OMA:AGFG2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 100,539,203 bp End 100,568,220 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 137,648,725 bp End 137,682,988 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland right adrenal cortex left adrenal gland right ovary left adrenal cortex left ovary right lobe of liver mucosa of transverse colon minor salivary glands body of uterus Top expressed in thymus saccule otic vesicle Rostral migratory stream dentate gyrus of hippocampal formation granule cell otic placode right kidney olfactory tubercle tibiofemoral joint granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding GTPase activator activity molecular function Cellular component membrane Biological process positive regulation of GTPase activity biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3268 231801 Ensembl ENSG00000106351 ENSMUSG00000029722 UniProt O95081 Q80WC7 RefSeq (mRNA) NM_006076 NM_145566 NM_178162 NM_001303266 NM_001303271 RefSeq (protein) NP_006067 NP_001290195 NP_001290200 NP_835456 Location (UCSC) Chr 7: 100.54 – 100.57 Mb Chr 5: 137.65 – 137.68 Mb PubMed search
Wikidata
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Arf-GAP domain and FG repeats-containing protein 2 is a protein that in humans is encoded by the AGFG2 gene.

This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000106351 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029722 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
6. ^ "Entrez Gene: HRBL HIV-1 Rev binding protein-like".

Further reading

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
• Doria M, Salcini AE, Colombo E, et al. (2000). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport". J. Cell Biol. 147 (7): 1379–84. doi:10.1083/jcb.147.7.1379. PMC 2174238. PMID 10613896.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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