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Halocidin

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Halocidin
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C155H251N47O38S2/c1-73(2)41-100(181-121(206)63-170-134(217)109(51-91-59-163-69-172-91)190-146(229)111(53-93-61-165-71-174-93)192-144(227)107(48-80(15)16)188-141(224)104(45-77(9)10)185-127(210)84(23)158)139(222)195-114(56-119(161)204)148(231)199-116(150(233)177-85(24)128(211)183-98(37-31-33-39-156)132(215)168-65-123(208)201-125(82(19)20)152(235)197-102(43-75(5)6)136(219)179-88(27)154(237)238)67-241-242-68-117(151(234)178-86(25)129(212)184-99(38-32-34-40-157)133(216)169-66-124(209)202-126(83(21)22)153(236)198-103(44-76(7)8)137(220)180-89(28)155(239)240)200-149(232)115(57-120(162)205)196-140(223)101(42-74(3)4)182-122(207)64-171-135(218)110(52-92-60-164-70-173-92)191-147(230)112(54-94-62-166-72-175-94)193-145(228)108(49-81(17)18)189-142(225)105(46-78(11)12)186-130(213)87(26)176-138(221)113(55-118(160)203)194-143(226)106(47-79(13)14)187-131(214)96(159)50-90-58-167-97-36-30-29-35-95(90)97/h29-30,35-36,58-62,69-89,96,98-117,125-126,167H,31-34,37-57,63-68,156-159H2,1-28H3,(H2,160,203)(H2,161,204)(H2,162,205)(H,163,172)(H,164,173)(H,165,174)(H,166,175)(H,168,215)(H,169,216)(H,170,217)(H,171,218)(H,176,221)(H,177,233)(H,178,234)(H,179,219)(H,180,220)(H,181,206)(H,182,207)(H,183,211)(H,184,212)(H,185,210)(H,186,213)(H,187,214)(H,188,224)(H,189,225)(H,190,229)(H,191,230)(H,192,227)(H,193,228)(H,194,226)(H,195,222)(H,196,223)(H,197,235)(H,198,236)(H,199,231)(H,200,232)(H,201,208)(H,202,209)(H,237,238)(H,239,240)Key: VOWRCIUWDITXFQ-UHFFFAOYSA-N
SMILES
  • CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CSSCC(C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC4=CC=CC=C43)N)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)NC(=O)CNC(=O)C(CC5=CN=CN5)NC(=O)C(CC6=CN=CN6)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)N
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Halocidin is an antimicrobial peptide isolated from the Halocynthia aurantium species of tunicate. In mouse models, derivative peptides have shown efficacy in the treatment of fungicidal resistant Candida Albacans when used as a mouthwash additive.

References

  1. Jang WS, Kim KN, Lee YS, Nam MH, Lee IH (June 2002). "Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium". FEBS Letters. 521 (1–3): 81–6. Bibcode:2002FEBSL.521...81J. doi:10.1016/s0014-5793(02)02827-2. PMID 12067731. S2CID 45780988.
  2. Jang WS, Lee SC, Lee YS, Shin YP, Shin KH, Sung BH, et al. (November 2007). "Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection". Antimicrobial Agents and Chemotherapy. 51 (11): 4148–4156. doi:10.1128/AAC.00635-07. PMC 2151467. PMID 17846130.
  3. Shin SH, Lee YS, Shin YP, Kim B, Kim MH, Chang HR, et al. (May 2013). "Therapeutic efficacy of halocidin-derived peptide HG1 in a mouse model of Candida albicans oral infection". The Journal of Antimicrobial Chemotherapy. 68 (5): 1152–1160. doi:10.1093/jac/dks513. PMID 23302580.
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