Helfer is a surname. Notable people with the surname include:
- Al Helfer (1911–1975), American sportscaster
- Andy Helfer (born 1958), American comics writer
- Erwin Helfer (born 1936), American pianist
- Johann Wilhelm Helfer (1810–1840), Bohemian scientist
- Laurence Helfer (born 1965), American lawyer
- Ralph Helfer (born 1931), American animal behaviorist
- Tricia Helfer (born 1974), Canadian actress
See also
- Charles d'Helfer (1598–1661), French composer
- Helfer, rank
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