Heme ligase - Misplaced Pages

Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe:ferriprotoporphyrin IX ligase (β-hematin-forming). This enzyme catalyses the following reaction:

2 ferriprotoporphyrin IX

\rightleftharpoons

beta-hematin

This heme detoxifying enzyme is found in Plasmodium parasites.

References

Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D (April 2008). "HDP-a novel heme detoxification protein from the malaria parasite". PLOS Pathogens. 4 (4): e1000053. doi:10.1371/journal.ppat.1000053. PMC 2291572. PMID 18437218.

External links

Heme+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 4.99.1