Henry O'Brien may refer to:
- Henry O'Brien, Lord Ibrackan (c. 1642–1678), Irish nobleman and politician
- Henry O'Brien, 5th Earl of Thomond (1588–1639), Irish peer
- Henry O'Brien, 7th Earl of Thomond (c. 1620–1691), Irish peer
- Henry O'Brien, 8th Earl of Thomond (1688–1741), Irish peer and Member of Parliament
- Henry O'Brien (Australian politician) (1793–1866), Irish-born New South Wales politician
- Henry O'Brien (classicist) (1808–1835), Irish classicist and author
- Henry O'Brien (colonel) (died 1863), colonel of the 11th New York Volunteer Infantry Regiment killed during the New York draft riots
- Henry O'Brien (cyclist) (1910–1973), American cyclist
- Henry D. O'Brien (1842–-1902), Medal of Honor recipient from the American Civil War
- Henry Joseph O'Brien (1896–1976), American prelate of the Roman Catholic Church
- Henry L. O'Brien (c. 1869–1935), American politician from New York
- Henry X. O'Brien (c. 1903–1990), American lawyer and judge
Topics referred to by the same termThis disambiguation page lists articles about people with the same name. If an internal link led you here, you may wish to change the link to point directly to the intended article. Category: