Homole may refer to:
Czech Republic
- Homole (České Budějovice District), a municipality and village in the South Bohemian Region
- Homole, former name of Homole u Panny, a municipality and village in the Ústí nad Labem Region
- Homole, a village and part of Borovnice (Rychnov nad Kněžnou District) in the Hradec Králové Region, a pilgrimage site
- Homole, a village and part of Drhovy in the Central Bohemian Region
- Homole, mountain in the Hrubý Jeseník range
Greece
- Homolium or Homole, a town of ancient Thessaly
Poland
- Homole, a castle in Lower Silesian Voivodeship
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