Misplaced Pages

Hypotonic-hyporesponsive episode

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Medical condition
Hypotonic-hyporesponsive episode (HHE)
SymptomsHypotonia, hyporesponsiveness, pallor, cyanosis.
Usual onset1 minute to 48 hours post-vaccination.
Duration1 minute to 14 days (median 10 hours).
CausesVaccination, most commonly pertussis vaccine.
Diagnostic methodBased on symptoms.
Differential diagnosisVasovagal syncope, seizure
PreventionThose who experience an HHE after pertussis vaccination may avoid further pertussis vaccines.
TreatmentUsually resolves on its own, management involves checking the airway, breathing, and circulation, and hospitalization for observation and to rule out other conditions.
DeathsNone reported

A hypotonic-hyporesponsive episode (HHE) is defined as sudden onset of poor muscle tone, reduced consciousness, and pale or bluish skin occurring within 48 hours after vaccination, most commonly pertussis vaccination. An HHE is estimated to occur after 1 in 4,762 to 1 in 1,408 doses of whole cell pertussis vaccine, and after 1 in 14,286 to 1 in 2,778 doses of acellular pertussis vaccine.

References

  1. ^ "Hypotonic, hyporesponsive episode (HHE)" (PDF). 7 January 2006. Retrieved 2018-01-24.
  2. ^ Duvernoy, Tracy S.; Braun, M. Miles (October 2000). "Hypotonic–Hyporesponsive Episodes Reported to the Vaccine Adverse Event Reporting System (VAERS), 1996–1998". Pediatrics. 106 (4): e52. doi:10.1542/peds.106.4.e52. PMID 11015547. S2CID 12743062. Retrieved 2018-01-22.
  3. ^ Bonhoeffer, Jan. "Hypotonic-hyporesponsive episode (HHE) as an adverse event following immunization in early childhood: Case definition and guidelines for data collection, analysis, and presentation". Vaccine. PMID 17537554. Retrieved 2018-02-01.
  4. "Chapter 16: Pertussis". CDC. Retrieved 2018-01-24.
  5. "Hypotonic-Hyporesponsive Episodes to Immunisation".
  6. Duvernoy, Tracy S.; Braun, M. Miles (October 2000). "Hypotonic–Hyporesponsive Episodes Reported to the Vaccine Adverse Event Reporting System (VAERS), 1996–1998". Pediatrics. 106 (4): e52. doi:10.1542/peds.106.4.e52. PMID 11015547. S2CID 12743062. Retrieved 2018-01-24.
Stub icon

This medical symptom article is a stub. You can help Misplaced Pages by expanding it.

Categories: