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ITGB1BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DX8, 4DX9, 4JIF
Identifiers
Aliases	ITGB1BP1, ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B, integrin subunit beta 1 binding protein 1
External IDs	OMIM: 607153; MGI: 1306802; HomoloGene: 3496; GeneCards: ITGB1BP1; OMA:ITGB1BP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p25.1 Start 9,403,475 bp End 9,423,528 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A1.3 Start 21,290,826 bp End 21,336,285 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix subcutaneous adipose tissue abdominal fat tibial nerve right frontal lobe caudate nucleus putamen gastric mucosa apex of heart C1 segment Top expressed in seminiferous tubule spermatid cerebellar cortex white adipose tissue lobe of cerebellum cerebellar vermis morula nucleus accumbens olfactory tubercle granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding kinase binding protein binding GDP-dissociation inhibitor activity protein kinase binding protein-containing complex binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion ruffle plasma membrane perinuclear region of cytoplasm cytoskeleton nucleus lamellipodium cell periphery nucleoplasm microtubule organizing center nuclear body Biological process Notch signaling pathway positive regulation of protein targeting to membrane cell differentiation activation of protein kinase B activity myoblast migration negative regulation of fibroblast migration regulation of cell adhesion mediated by integrin intracellular signal transduction positive regulation of protein kinase B signaling regulation of transcription, DNA-templated negative regulation of protein kinase activity regulation of GTPase activity biomineral tissue development negative regulation of protein binding cellular response to fibroblast growth factor stimulus receptor clustering blood vessel endothelial cell proliferation involved in sprouting angiogenesis transcription, DNA-templated positive regulation of endothelial cell migration negative regulation of cell adhesion involved in substrate-bound cell migration negative regulation of cell migration involved in sprouting angiogenesis negative regulation of protein targeting to membrane tube formation regulation of integrin-mediated signaling pathway cell adhesion angiogenesis positive regulation of cell population proliferation protein transport integrin-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of focal adhesion assembly cellular response to vascular endothelial growth factor stimulus integrin activation cell-matrix adhesion negative regulation of substrate adhesion-dependent cell spreading cell migration negative regulation of focal adhesion assembly positive regulation of cell division positive regulation of stress fiber assembly positive regulation of Notch signaling pathway negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9270 16413 Ensembl ENSG00000119185 ENSMUSG00000062352 UniProt O14713 O35671 RefSeq (mRNA) NM_004763 NM_022334 NM_001319066 NM_001319067 NM_001319068 NM_001319069 NM_001319070 NM_001369744 NM_001369745 NM_001369746 NM_001369747 NM_001369748 NM_001369749 NM_001369750 NM_008403 NM_001355609 RefSeq (protein) NP_001305995 NP_001305996 NP_001305997 NP_001305998 NP_001305999 NP_004754 NP_071729 NP_001356673 NP_001356674 NP_001356675 NP_001356676 NP_001356677 NP_001356678 NP_001356679 NP_032429 NP_001342538 Location (UCSC) Chr 2: 9.4 – 9.42 Mb Chr 12: 21.29 – 21.34 Mb PubMed search
Wikidata
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Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion.

Interactions

ITGB1BP1 has been shown to interact with KRIT1, LRP2, CD29 and LRP1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000119185 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000062352 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Zawistowski JS, Serebriiskii IG, Lee MF, Golemis EA, Marchuk DA (March 2002). "KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis". Hum Mol Genet. 11 (4): 389–96. doi:10.1093/hmg/11.4.389. PMID 11854171.
6. ^ Chang DD, Wong C, Smith H, Liu J (October 1997). "ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin". J Cell Biol. 138 (5): 1149–57. doi:10.1083/jcb.138.5.1149. PMC 2136751. PMID 9281591.
7. ^ "Entrez Gene: ITGB1BP1 integrin beta 1 binding protein 1".
8. Zhang, J; Clatterbuck R E; Rigamonti D; Chang D D; Dietz H C (December 2001). "Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation". Hum. Mol. Genet. 10 (25). England: 2953–60. doi:10.1093/hmg/10.25.2953. ISSN 0964-6906. PMID 11741838.
9. ^ Gotthardt, M; Trommsdorff M; Nevitt M F; Shelton J; Richardson J A; Stockinger W; Nimpf J; Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33). UNITED STATES: 25616–24. doi:10.1074/jbc.M000955200. ISSN 0021-9258. PMID 10827173.
10. Chang, David D; Hoang Bao Q; Liu Jenny; Springer Timothy A (March 2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". J. Biol. Chem. 277 (10). United States: 8140–5. doi:10.1074/jbc.M109031200. ISSN 0021-9258. PMID 11741908.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Bouvard D, Block MR (1998). "Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha". Biochem. Biophys. Res. Commun. 252 (1): 46–50. doi:10.1006/bbrc.1998.9592. PMID 9813144.
• Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
• Zhang J, Clatterbuck RE, Rigamonti D, et al. (2002). "Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation". Hum. Mol. Genet. 10 (25): 2953–60. doi:10.1093/hmg/10.25.2953. PMID 11741838.
• Chang DD, Hoang BQ, Liu J, Springer TA (2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". J. Biol. Chem. 277 (10): 8140–5. doi:10.1074/jbc.M109031200. PMID 11741908.
• Fournier HN, Dupé-Manet S, Bouvard D, et al. (2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895–902. doi:10.1074/jbc.M200200200. PMID 11919189.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Xia H, Nho RS, Kahm J, et al. (2004). "Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway". J. Biol. Chem. 279 (31): 33024–34. doi:10.1074/jbc.M313265200. PMID 15166238.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fournier HN, Dupé-Manet S, Bouvard D, et al. (2005). "Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation". Mol. Biol. Cell. 16 (4): 1859–71. doi:10.1091/mbc.E04-08-0744. hdl:2318/38098. PMC 1073667. PMID 15703214.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Stroeken PJ, Alvarez B, Van Rheenen J, et al. (2006). "Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane". J. Cell. Physiol. 208 (3): 620–8. doi:10.1002/jcp.20699. PMID 16741948. S2CID 23448867.
• Furusu A, Nakayama K, Xu Q, et al. (2007). "MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha". J. Cell. Physiol. 210 (3): 703–10. doi:10.1002/jcp.20881. PMID 17133355. S2CID 84971749.

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