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Ilhéu de Santana is an uninhabited island in the Gulf of Guinea and is one of the smaller islands of São Tomé and Príncipe. The islet is located 0.7 nmi (1.3 km) off the east coast of the island of São Tomé near the town of Santana in Cantagalo District. It is 50 metres high. The islet was mentioned in the 1616 map by Jodocus Hondius as I. de S. Anne.