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This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages) This article possibly contains original research. Please improve it by verifying the claims made and adding inline citations. Statements consisting only of original research should be removed. (May 2008) (Learn how and when to remove this message) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Isograft" – news · newspapers · books · scholar · JSTOR (September 2014) (Learn how and when to remove this message) (Learn how and when to remove this message)

An Isograft is a graft of tissue between two individuals who are genetically identical (i.e. monozygotic twins). Transplant rejection between two such individuals virtually never occurs, making isografts particularly relevant to organ transplantations; patients with organs from their identical twins are incredibly likely to receive the organs favorably and survive. Monozygotic twins have the same major histocompatibility complex, leading to the low instances of tissue rejection by the adaptive immune system. Furthermore, there is virtually no incidence of graft-versus-host disease.

In 1993 a research article demonstrated that islet isografts were being transplanted into young diabetic mice and the mice survived at least about 22 days post transplantation.

References

1. Effect of STZ Administration on Islet Isograft and Allograft Survival in NOD Mice. Diabetes Vol 42, February 1993. Retrieved 25 June 2014.

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