2-Isopropylmalic acid | |
3-Isopropylmalic acid | |
Names | |
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IUPAC names
3-Isopropylmalic acid 2-Hydroxy-3-isopropylsuccinic acid | |
Other names Isopropylmalate | |
Identifiers | |
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3D model (JSmol) |
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ChemSpider | |
DrugBank |
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ECHA InfoCard | 100.159.209 |
EC Number |
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CompTox Dashboard (EPA) | |
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Properties | |
Chemical formula | C7H12O5 |
Molar mass | 176.168 g·mol |
Hazards | |
GHS labelling: | |
Pictograms | |
Signal word | Warning |
Hazard statements | H315, H319, H335 |
Precautionary statements | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references |
Isopropylmalic acid (isopropylmalate) is an intermediate in the biosynthesis of leucine, synthesized from oxoisovalerate by 2-isopropylmalate synthase and converted into isopropyl-3-oxosuccinate by 3-isopropylmalate dehydrogenase. Two isomers are important, the 2- and 3-isopropyl derivatives, and these are interconverted by isopropylmalate dehydratase.
References
- Strassman, Murray; Ceci, Louis N. (1963). "Enzymatic Formation of α-Isopropylmalic Acid, an Intermediate in Leucine Biosynthesis". Journal of Biological Chemistry. 238 (7): 2445–2452. doi:10.1016/S0021-9258(19)67991-3. PMID 13978769.
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