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Itruvone

Clinical data
Other names	PH10; PH10A; PH10 NS; Pregn-4-en-20-yn-3-one
Routes of administration	Intranasal (spray)
Identifiers
IUPAC name (8S,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopentaphenanthren-3-one
CAS Number	21321-89-1
PubChem CID	15633961
ChemSpider	18829396
UNII	72HML2UK6J
KEGG	D12542
Chemical and physical data
Formula	C21H28O
Molar mass	296.454 g·mol
3D model (JSmol)	Interactive image
SMILES C12CC3(1CC2C#C)CCC4=CC(=O)CC34C
InChI InChI=1S/C21H28O/c1-4-14-6-8-18-17-7-5-15-13-16(22)9-11-21(15,3)19(17)10-12-20(14,18)2/h1,13-14,17-19H,5-12H2,2-3H3/t14-,17-,18-,19-,20+,21-/m0/s1 Key:CHOUAXDNNAVGHR-NWSAAYAGSA-N

Itruvone (INNTooltip International Nonproprietary Name; developmental code name PH10), also known as pregn-4-en-20-yn-3-one, is a vomeropherine which is under development by VistaGen Therapeutics as a nasal spray for the treatment of major depressive disorder.

See also

• List of investigational antidepressants
• List of neurosteroids § Pheromones and pherines

References

1. "PH-10 Nasal Spray". AdisInsight. Springer Nature Switzerland AG.
2. Monti L, Liebowitz MR (February 2022). "Neural circuits of anxiolytic and antidepressant pherine molecules". CNS Spectr. 27 (1): 66–72. doi:10.1017/S109285292000190X. PMID 33092667. S2CID 225053518.
3. "VistaGen Therapeutics Acquires Worldwide Rights to Develop and Commercialize PH10, a First-in-Class Intranasally Administered Neuroactive Steroid with Rapid-onset Antidepressant Effects for Major Depressive Disorder Demonstrated in Phase 2a Study :: VistaGen Therapeutics, Inc. (VTGN)". VistaGen Therapeutics, Inc. Retrieved 2019-12-19.
4. "Health Care Digest: A small biotech goes head first, Gilead's lower tax rate and more". www.bizjournals.com. San Francisco Business Times. October 29, 2018. Retrieved 20 July 2020.
5. Liebowitz MR, Nicolini H, Monti L, Hanover R (2013). PH 10 may be a new rapidly acting intranasally administered antidepressant. Vol. American Society of Clinical Psychopharmacology (ASCP) Annual Meeting, Miami, FL.
6. Jancin B (2013). "Novel intranasal antidepressant shows results after 1 week". Clinical Psychiatry News. Retrieved 13 January 2016.

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