James Patton may refer to:
- James Patton (Virginia colonist) (1692-1755) Irish immigrant who lived in colonial Virginia
- James French Patton (1843–1882), American soldier and judge
- Jimmy Patton (1933–1972), American football player
- Jim Patton (brewer) (1953–2012), American anthropologist and craft beer brewer
- James L. Patton (born 1941), American mammalogist
- James Patton (defensive lineman) (born 1970), American football player
- James Patton (American football coach), American football player and coach
- James Patton (baseball), American baseball player
- James Patton (born 1965), American military officer, engineer
- James Patton (politician) (1780–1830), Lieutenant Governor of Mississippi
- James D. Patton (1850–1925), American politician in the Virginia House of Delegates
See also
- James "Squire" Patton House, historic house in New Windsor, New York
- James Paton (disambiguation)
- James A. Patten (1852–1928), American financier and grain merchant
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