| Joan Blanchette Broderick | |
|---|---|
| Alma mater | Northwestern University |
| Scientific career | |
| Institutions | Montana State University |
| Thesis | Spectroscopic and mechanistic studies of chlorocatechol dioxygenase, a non-heme iron dioxygenase with broad substrate tolerance (1992) |
Joan Blanchette Broderick is a professor of chemistry and biochemistry at Montana State University known for her work on bioinorganic chemistry, especially the chemistry of iron-sulfur interactions. She was elected a member of the National Academy of Sciences in 2022.
Education and career
Broderick has an undergraduate degree from Washington State University, and an M.S. and a PhD from Northwestern University. Following her Ph.D., she was a postdoc at Massachusetts Institute of Technology and then an assistant professor at Amherst College. She held a faculty position at Michigan State University before moving to Montana in 2005.
She has been recognized as a Saltman Lecturer and Women in Science Distinguished Professor at Montana State University. In 2019, Broderick received the Alfred Bader Award in Bioinorganic or Bioorganic Chemistry from the American Chemical Society.
Research
She has contributed to bioinorganic chemistry often with a focus on iron-sulfur proteins, including the radical SAM enzymes. Her research also includes investigations into hydrogenase where she defines the assembly of the enzymes into functional units.
Selected publications
- Mulder, David W.; Boyd, Eric S.; Sarma, Ranjana; Lange, Rachel K.; Endrizzi, James A.; Broderick, Joan B.; Peters, John W. (May 2010). "Stepwise -hydrogenase H-cluster assembly revealed in the structure of HydAΔEFG". Nature. 465 (7295): 248–251. Bibcode:2010Natur.465..248M. doi:10.1038/nature08993. PMID 20418861. S2CID 1990191.
- Peters, John W.; Schut, Gerrit J.; Boyd, Eric S.; Mulder, David W.; Shepard, Eric M.; Broderick, Joan B.; King, Paul W.; Adams, Michael W. W. (1 June 2015). "[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1853 (6): 1350–1369. doi:10.1016/j.bbamcr.2014.11.021. ISSN 0167-4889. PMID 25461840.
- Broderick, Joan B.; Duffus, Benjamin R.; Duschene, Kaitlin S.; Shepard, Eric M. (23 April 2014). "Radical S -Adenosylmethionine Enzymes". Chemical Reviews. 114 (8): 4229–4317. doi:10.1021/cr4004709. PMC 4002137. PMID 24476342.
References
- "2022 NAS Election".
- "People". Broderick Research Group. 2017-10-09. Retrieved 2021-10-07.
- "Joan Broderick - Chemistry and Biochemistry - Montana State University". www.chemistry.montana.edu.
- "2019 ACS National Award winners". Chemical & Engineering News. Retrieved 2019-01-22.
- Broderick, J. B.; Duffus, B. R.; Duschene, K. S.; Shepard, E. M., "Radical S-Adenosylmethionine Enzymes", Chemical Reviews 2014, volume 114, 4229-4317. 10.1021/cr4004709
- Shepard, Eric M.; McGlynn, Shawn E.; Bueling, Alexandra L.; Grady-Smith, Celestine S.; George, Simon J.; Winslow, Mark A.; Cramer, Stephen P.; Peters, John W.; Broderick, Joan B. (2010-06-08). "Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold". Proceedings of the National Academy of Sciences. 107 (23): 10448–10453. Bibcode:2010PNAS..10710448S. doi:10.1073/pnas.1001937107. ISSN 0027-8424. PMC 2890834. PMID 20498089.
- Peters, John W.; Broderick, Joan B. (2012-07-07). "Emerging Paradigms for Complex Iron-Sulfur Cofactor Assembly and Insertion". Annual Review of Biochemistry. 81 (1): 429–450. doi:10.1146/annurev-biochem-052610-094911. ISSN 0066-4154. PMID 22482905.
External links
- Joan B. Broderick publications indexed by Google Scholar