John Rodríguez may refer to:
Entertainment
- Johnny Rodriguez, American singer
- Johnny "Dandy" Rodríguez, American percussionist
- Johnny Ray Rodríguez or Johnny Ray, American comedian born
Sports
- John Rodriguez (baseball), American baseball player
- Johnny Rodríguez (basketball), Puerto Rican basketball player
- Jhon Édison Rodríguez, Colombian fencer
- Johnny Rodriguez (soccer), American soccer player
Others
- John Rodriguez (politician) (1937–2017), Guyanese-born Canadian politician
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