Křížek (feminine Křížková) is a Czech surname. Notable people with the surname include:
- Matthias Krizek (born 1988), Austrian cyclist
- Milan Křížek (1926-2018), Czech composer, music teacher and viola player
- Paul Krizek (born 1961), American politician
- Šárka Křížková, Czech badminton player
- Zdeněk Křížek (born 1983), Czech footballer
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