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KPNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JDQ, 3TJ3, 4B18
Identifiers
Aliases	KPNA1, IPOA5, NPI-1, RCH2, SRP1, Importin, Karyopherin alpha 1, karyopherin subunit alpha 1
External IDs	OMIM: 600686; MGI: 103560; HomoloGene: 55642; GeneCards: KPNA1; OMA:KPNA1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.1 Start 122,421,902 bp End 122,514,945 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 35,799,120 bp End 35,857,501 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes biceps brachii sural nerve deltoid muscle gastrocnemius muscle endothelial cell Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis triceps brachii muscle tibialis anterior muscle Top expressed in triceps brachii muscle otic vesicle gastrocnemius muscle vastus lateralis muscle muscle of thigh extensor digitorum longus muscle medial head of gastrocnemius muscle temporal muscle blood sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear localization sequence binding nuclear import signal receptor activity Cellular component nuclear pore nucleoplasm dendrite nucleus cytoplasm cytosol host cell postsynaptic density glutamatergic synapse Biological process regulation of DNA recombination intracellular transport of virus apoptotic DNA fragmentation protein import into nucleus protein transport modulation by virus of host cellular process NLS-bearing protein import into nucleus viral process postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3836 16646 Ensembl ENSG00000114030 ENSMUSG00000022905 UniProt P52294 Q60960 RefSeq (mRNA) NM_002264 NM_008465 RefSeq (protein) NP_002255 NP_032491 Location (UCSC) Chr 3: 122.42 – 122.51 Mb Chr 16: 35.8 – 35.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Importin subunit alpha-5 is a protein that in humans is encoded by the KPNA1 gene.

Interactions

Importin subunit alpha-5 has been shown to interact with KPNB1 and UBR5.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000114030 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022905 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cortes P, Ye ZS, Baltimore D (Sep 1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A. 91 (16): 7633–7. Bibcode:1994PNAS...91.7633C. doi:10.1073/pnas.91.16.7633. PMC 44456. PMID 8052633.
6. Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. 19 (11). UNITED STATES: 7782–91. doi:10.1128/mcb.19.11.7782. ISSN 0270-7306. PMC 84838. PMID 10523667.
7. Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. 266 (4). ENGLAND: 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465.
8. Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. 277 (29). United States: 26468–78. doi:10.1074/jbc.M203527200. hdl:1885/64590. ISSN 0021-9258. PMID 12011095.

Further reading

• Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader". Front. Biosci. 2 (4): d578–87. doi:10.2741/A213. PMID 9366553.
• Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. doi:10.1007/BF03401911. PMC 2230352. PMID 9562972.
• Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
• Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. Bibcode:1992PNAS...89.6580B. doi:10.1073/pnas.89.14.6580. PMC 49545. PMID 1631159.
• Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells". AIDS Res. Hum. Retroviruses. 7 (3): 303–6. doi:10.1089/aid.1991.7.303. PMID 2064827.
• Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. doi:10.1128/JVI.69.12.7909-7916.1995. PMC 189735. PMID 7494303.
• Gallay P, Swingler S, Song J, et al. (1995). "HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase". Cell. 83 (4): 569–76. doi:10.1016/0092-8674(95)90097-7. PMID 7585960. S2CID 15536328.
• Moroianu J, Hijikata M, Blobel G, Radu A (1995). "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6532–6. Bibcode:1995PNAS...92.6532M. doi:10.1073/pnas.92.14.6532. PMC 41552. PMID 7604027.
• Freed EO, Englund G, Martin MA (1995). "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection". J. Virol. 69 (6): 3949–54. doi:10.1128/JVI.69.6.3949-3954.1995. PMC 189124. PMID 7745752.
• Weis K, Mattaj IW, Lamond AI (1995). "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences". Science. 268 (5213): 1049–53. Bibcode:1995Sci...268.1049W. doi:10.1126/science.7754385. PMID 7754385.
• O'Neill RE, Palese P (1995). "NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein". Virology. 206 (1): 116–25. doi:10.1016/S0042-6822(95)80026-3. PMID 7831767.
• Gallay P, Swingler S, Aiken C, Trono D (1995). "HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator". Cell. 80 (3): 379–88. doi:10.1016/0092-8674(95)90488-3. PMID 7859280. S2CID 15064293.
• Moroianu J, Blobel G, Radu A (1995). "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2008–11. Bibcode:1995PNAS...92.2008M. doi:10.1073/pnas.92.6.2008. PMC 42412. PMID 7892216.
• von Schwedler U, Kornbluth RS, Trono D (1994). "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. Bibcode:1994PNAS...91.6992V. doi:10.1073/pnas.91.15.6992. PMC 44324. PMID 8041734.
• Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. Bibcode:1994PNAS...91.7311H. doi:10.1073/pnas.91.15.7311. PMC 44389. PMID 8041786.
• Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells". Nature. 365 (6447): 666–9. Bibcode:1993Natur.365..666B. doi:10.1038/365666a0. PMC 9524217. PMID 8105392. S2CID 25678.
• Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention". Mol. Med. 1 (2): 217–30. doi:10.1007/BF03401569. PMC 2229944. PMID 8529100.
• Gallay P, Stitt V, Mundy C, et al. (1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import". J. Virol. 70 (2): 1027–32. doi:10.1128/JVI.70.2.1027-1032.1996. PMC 189908. PMID 8551560.
• Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996). "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. Bibcode:1996PNAS...93..367B. doi:10.1073/pnas.93.1.367. PMC 40239. PMID 8552640.

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