Karunanayake is a surname. Notable people with the surname include:
- Kamal Karunanayake (1937–2006), Sri Lankan politician
- Nipun Karunanayake (born 1991), Sri Lankan cricketer
- Ravi Karunanayake (born 1963), Sri Lankan politician
- Shalika Karunanayake (born 1987), Sri Lankan cricketer
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