Knysh (Ukrainian: Книш) is a Ukrainian-language surname. Notable people with this surname include:
- Danylo Knysh (born 1996), Ukrainian football midfielder
- Myhaylo Knysh (born 1983), Ukrainian sprinter
- Olha Knysh (born 1995), former female alpine skier from Ukraine
- Renald Knysh (1931–2019), Soviet and Belarusian coach in artistic gymnastics
- Valentin Knysh (1937–2022), Russian politician
- Volodymyr Knysh (born 1970), former Soviet and Ukrainian footballer
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