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Galectin-7

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(Redirected from LGALS7) Protein-coding gene in the species Homo sapiens
LGALS7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UW5, 2GAL, 4GAL, 1BKZ, 4UW4, 3ZXE, 3GAL, 3ZXF, 4UW6, 4XBQ, 5GAL, 4UW3, 5H9S, 4Y26, 5H9Q

Identifiers
AliasesLGALS7, GAL7, LGALS7A, galectin 7
External IDsOMIM: 600615; MGI: 1316742; HomoloGene: 100509; GeneCards: LGALS7; OMA:LGALS7 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for LGALS7Genomic location for LGALS7
Band19q13.2Start38,770,968 bp
End38,773,517 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for LGALS7Genomic location for LGALS7
Band7|7 B1Start28,563,278 bp
End28,565,709 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • olfactory zone of nasal mucosa

  • gonad

  • testicle

  • vagina

  • minor salivary glands

  • ectocervix

  • right lung

  • spleen
Top expressed in
  • lip

  • esophagus

  • skin of external ear

  • superior surface of tongue

  • skin of abdomen

  • skin of back

  • umbilical cord

  • epidermis

  • hair follicle

  • condyle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3963

16858

Ensembl

ENSG00000283082
ENSG00000205076

ENSMUSG00000053522

UniProt

P47929

O54974

RefSeq (mRNA)

NM_002307

NM_008496

RefSeq (protein)

NP_002298
NP_001035972

n/a

Location (UCSC)Chr 19: 38.77 – 38.77 MbChr 7: 28.56 – 28.57 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene.

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell–cell and/or cell–matrix interactions necessary for normal growth control.

References

  1. ^ ENSG00000205076 GRCh38: Ensembl release 89: ENSG00000283082, ENSG00000205076Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000053522Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Madsen P, Rasmussen HH, Flint T, Gromov P, Kruse TA, Honore B, Vorum H, Celis JE (Apr 1995). "Cloning, expression, and chromosome mapping of human galectin-7". J Biol Chem. 270 (11): 5823–29. doi:10.1074/jbc.270.11.5823. PMID 7534301.
  6. Magnaldo T, Bernerd F, Darmon M (May 1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
  7. ^ "Entrez Gene: LGALS7 lectin, galactoside-binding, soluble, 7 (galectin 7)".

Further reading

PDB gallery
  • 1bkz: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 1bkz: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7
  • 2gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE 2gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE
  • 3gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSAMINE 3gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSAMINE
  • 4gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE 4gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE
  • 5gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH N-ACETYLLACTOSAMINE 5gal: CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH N-ACETYLLACTOSAMINE


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