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LSM10
Identifiers
Aliases	LSM10, MST074, MSTP074, U7 small nuclear RNA associated
External IDs	OMIM: 617909; MGI: 2151045; HomoloGene: 13154; GeneCards: LSM10; OMA:LSM10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 36,391,238 bp End 36,397,908 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 125,990,416 bp End 125,992,377 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle granulocyte apex of heart monocyte right auricle skeletal muscle tissue tibialis anterior muscle quadriceps femoris muscle muscle layer of sigmoid colon Top expressed in interventricular septum primary oocyte granulocyte endocardial cushion yolk sac right kidney medial ganglionic eminence left lobe of liver embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function U7 snRNA binding protein binding histone pre-mRNA DCP binding RNA binding Cellular component Cajal body U7 snRNP nucleus nucleoplasm nuclear body Biological process positive regulation of G1/S transition of mitotic cell cycle termination of RNA polymerase II transcription mRNA processing histone mRNA metabolic process RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84967 116748 Ensembl ENSG00000181817 ENSMUSG00000050188 UniProt Q969L4 Q8QZX5 RefSeq (mRNA) NM_032881 NM_001163266 NM_138721 RefSeq (protein) NP_116270 NP_001156738 NP_620046 Location (UCSC) Chr 1: 36.39 – 36.4 Mb Chr 4: 125.99 – 125.99 Mb PubMed search
Wikidata
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U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene.

Interactions

LSM10 has been shown to interact with LSM3.

See also

• U7 small nuclear RNA

References

1. ^ GRCh38: Ensembl release 89: ENSG00000181817 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000050188 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B (Oct 2001). "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein" (PDF). The EMBO Journal. 20 (19): 5470–9. doi:10.1093/emboj/20.19.5470. PMC 125645. PMID 11574479.
6. "Entrez Gene: LSM10 LSM10, U7 small nuclear RNA associated".
7. Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

• Dominski Z, Zheng LX, Sanchez R, Marzluff WF (May 1999). "Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA". Molecular and Cellular Biology. 19 (5): 3561–70. doi:10.1128/mcb.19.5.3561. PMC 84148. PMID 10207079.
• Dominski Z, Erkmann JA, Yang X, Sànchez R, Marzluff WF (Jan 2002). "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing". Genes & Development. 16 (1): 58–71. doi:10.1101/gad.932302. PMC 155312. PMID 11782445.
• Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (Sep 2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes & Development. 17 (18): 2321–33. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
• Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S (May 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D (Oct 2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". The Journal of Biological Chemistry. 280 (41): 34435–40. doi:10.1074/jbc.M505077200. hdl:21.11116/0000-0007-E5F1-6. PMID 16087681.
• Wagner EJ, Marzluff WF (Sep 2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Molecular and Cellular Biology. 26 (17): 6702–12. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.

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