Lee–Boot effect - Misplaced Pages

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The Lee–Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and other rodents), when females are housed in groups and isolated from males. It is caused by the effects of an estrogen-dependent pheromone, possibly 2,5-dimethylpyrazine, which is released via the urine and acts on the vomeronasal organ of recipients. This pheromone lowers the concentration of luteinizing hormone and elevates prolactin levels, synchronising or stopping the recipient's cycle. This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice. The same response is invoked from isolated females when brought into contact with urine-soaked bedding from other females' cages. The adrenal glands are required for production of the urine pheromone which is responsible for this effect.

References

Lee, S. van der; Boot, L.M (1956). "Spontaneous Pseudopregnancy in Mice". Acta Physiol. Pharmacol. 5 (213). Neer.: 213–215. PMID 13402502.
"Mouse Husbandry, Breeding and Development: Pheromone Effects". Transgenic Mouse Facility, University of California.
^ Ma W, Miao Z, Novotny MV (1998). "Role of the adrenal gland and adrenal-mediated chemosignals in suppression of estrus in the house mouse: the Lee-Boot effect revisited". Biol Reprod. 59 (6): 1317–20. doi:10.1095/biolreprod59.6.1317. PMID 9828173.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Carlson, Neil R. (2013). Physiology of behavior (11th ed.). Boston: Pearson. p. 335. ISBN 978-0205239399.
Petrulis, Aras (May 2013). "Chemosignals, Hormones and Mammalian Reproduction". Hormones and Behavior. 65 (5): 723–41. doi:10.1016/j.yhbeh.2013.03.011. PMC 3667964. PMID 23545474.
Jemiolo, Bozena; Novotny, Milos (1994-03-01). "Inhibition of sexual maturation in juvenile female and male mice by a chemosignal of female origin". Physiology & Behavior. 55 (3): 519–522. doi:10.1016/0031-9384(94)90110-4. ISSN 0031-9384. PMID 8190771. S2CID 28082749.

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