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"Let's Shake Hands" was the first song the band recorded in their living room for Dave Buick, who offered to finance the release of their first single. The style surprised Buick based on the band's live performances, but—according to an interview with The New Yorker—Jack said it was "a declaration that the White Stripes weren’t going to observe punk proprieties." The song showcases the early garage punk sound of the band in its infancy. The single is backed with a cover of "Look Me Over Closely," a song written for Marlene Dietrich by folk musician Terry Gilkyson.
A second edition of 1,000 copies was pressed on black vinyl in 2002. The cover for this repressing was a better quality version of the original photo. There was a "secret" third pressing in 2008 with a stenciled version of the original cover art by Dion Fischer. It was pressed on black vinyl and 1,000 hand-numbered copies were produced. Highly coveted among diehard fans, this 7" remains one of the rarest and priciest items in The White Stripes' entire discography.