Leucosia may refer to any of the following:
- Leucosia (genus), a genus of crabs
- Leucosia, a possible name for one of the sirens of Greek mythology.
- Leucosia, a former name for Nicosia, Cyprus
- Kira Underwood, a deceased character in Ready Player One whose persona is Leucosia.
- Cyclone Leucosia, a powerful Mediterranean tropical-like cyclone which affected Malta, southern Italy, and Greece in 1982.
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