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Robert Emmett Hannegan (1903–1949) (J.D. 1925) – Commissioner of U.S. Internal Revenue (1943-1945); chairman, Democratic National Committee (1944-1947); U.S. Postmaster General (Truman administration, 1945–1947); President, St, Louis Cardinals (1947–1949)
Lester C. Hunt – Governor of Wyoming (1943-1949), U.S. Senator, Wyoming (1949-1954)
Charles A. Williams, Jr. - Rear Admiral USN, Presidential Appointment Assistant Secretary of the Navy, Governor Appointment Military Preparedness Commission
Science and medicine
Sridhar Condoor, Professor of Aerospace and Mechanical Engineering
Thomas Anthony Dooley (M.D. 1953) – Humanitarian, physician, and CIA operative who worked in Southeastern Asia; author of Deliver Us from Evil, The Edge of Tomorrow, and The Night They Burned the Mountain.
Mary Euphrasia Markham, one of the first women to earn a nursing diploma at Georgetown University. She earned it in 1920, 43 years before the university officially admitted women.
Richard G. Thomas (B.S. 1952) – (Aeronautical Engineering) Northrop test pilot – Tacit Blue; Secret Project/Area 51, F-5 Spin Tests, Edwards AFB, California.
Bob Ferry – Basketball All-American in 1958–59, enjoyed a ten-year career in the NBA with the St. Louis Hawks, Detroit Pistons, and Baltimore Bullets. Former assistant coach and general manager of the Baltimore Bullets; NBA Executive of the Year in 1979 and 1982.
Larry Hughes – NBA basketball player, attended but never graduated, was drafted after his freshman year into the NBA by the Philadelphia 76ers.
Brian McBride – First American to score in more than one FIFA World Cup tournament, doing so once in 1998 and twice in 2002. He is also SLU's all-time leading goal-scorer and held the freshman scoring record until 2003, when he was surpassed by Vedad Ibišević.
John Kaiser – M.H.M. Mill Hill Missionary died under suspicious circumstances while serving in Kenya. Received an Award for Distinguished Service in the Promotion of Human Rights from the Law Society of Kenya prior to his death.
Richard Stika – Third Bishop of the Diocese of Knoxville.
John Stowe, O.F.M. Conv. – Bishop of the Diocese of Lexington in Kentucky
Sister Rose Thering O.P. (Ph.D. 1961) – Dominican nun whose campaign against anti-Semitism in Catholic textbooks is the subject of the Oscar-nominated 39-minute documentary film directed by Oren Jacoby, Sister Rose's Passion.
Bobby Wilks – First African American Coast Guard aviator, the first African American to reach the rank of captain in the Coast Guard and the first African American to command a Coast Guard air station.
Edward Rice – Seventh Bishop of the Diocese of Springfield – Cape Girardeau.
Marshall McLuhan (1937-1944) – well known for coining the expressions "the medium is the message" and the "global village".
Kurt Schuschnigg (1948-1967) – Chancellor of Austria from 1934 to 1938. An ally of Mussolini who continued the conservative, authoritarian and pro-Catholic state established by assassinated chancellor Engelbert Dollfuß (often referred to as “Austrofascism”), Schuschnigg is also known for advocating continued Austrian national sovereignty as opposed to annexation or Anschluss by the Third Reich and for suppression of political opposition within Austria, including the communists, social democrats and Nazis. He was pressured to resign by Hitler during his country's annexation by Germany and interned in Dachau concentration camp.
Clarence H. Miller – Emeritus Professor of English known for his contributions to the study of Renaissance literature, including his translations of St. Thomas More's Utopia and Erasmus's Praise of Folly.
Thomas F. Madden – historian of Venice and the crusades; author of The New Concise History of the Crusades and Enrico Dandolo and the Rise of Venice
"John M. Nations" (PDF). Federal Railroad Administration. U.S. Department of Transportation. 2012. Archived (PDF) from the original on April 29, 2017. Retrieved 20 December 2017.