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Throughout the 1990s and 2000s, Bergen had guest starred as Murphy Brown on various television programs, though in 2005, she began starring on the spin-off series to The Practice, portraying Shirley Schmidt on Boston Legal from 2005 to 2008. It garnered her critical acclaim, receiving additional Golden Globe and Primetime Emmy Award nominations; as well as five Screen Actors Guild Award nominations for her individual role and for the main cast of Boston Legal.
Bergen is widely known mainly for her television work. Though she has been nominated for one Academy Award, one BAFTA Award, and two additional Golden Globe Award nominations for her work in film.