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Long-chain-enoyl-CoA hydratase

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long-chain-enoyl-CoA hydratase
Identifiers
EC no.4.2.1.74
CAS no.62009-81-8
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The enzyme long-chain-enoyl-CoA hydratase (EC 4.2.1.74) catalyzes the chemical reaction

(3S)-3-hydroxyacyl-CoA {\displaystyle \rightleftharpoons } trans-2-enoyl-CoA + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase. This enzyme is also called long-chain enoyl coenzyme A hydratase. This enzyme participates in fatty acid elongation in mitochondria and fatty acid metabolism.

References

  • Fong JC, Schulz H (1977). "Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues". J. Biol. Chem. 252 (2): 542–7. PMID 833142.
  • Schulz H (1974). "Long chain enoyl coenzyme A hydratase from pig heart". J. Biol. Chem. 249 (9): 2704–9. PMID 4828315.
Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases
4.2.2: Acting on polysaccharides
4.2.3: Acting on phosphates
4.2.99: Other
Enzymes
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