Loyola is a Basque surname. Notable people with the surname include:
- Ángel Custodio Loyola (1926–1985), Venezuelan singer and composer
- Carlos Díaz Loyola (1894–1968), Chilean poet, known as Pablo de Rokha
- Ignacio Loyola Vera (born 1954), Mexican politician
- Ignatius of Loyola (1491–1556), Catholic saint and founder of the Society of Jesus
- José Inácio Candido de Loyola (1891-1973), Goan Catholic independence activist
- Juan Loyola (1952–1999), Venezuelan artist
- Margot Loyola (1918-2015), Chilean musician
- Martín Ignacio de Loyola (1550–1616), Franciscan friar and circumnavigator
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