Lukes is a surname. Notable people with the surname include:
- František Lukeš, Czech ice hockey player
- Jaroslav Lukeš, Czech skier
- Konstantina Lukes, American state politician
- Martin Lukeš (born 1978), Czech footballer
- Nathan Lukes (born 1994), American baseball player
- Radek Lukeš (born 1979), Czech ice hockey goaltender
- Steven Lukes (born 1941), English academic
- William F. Lukes (1847–1923), United States Navy sailor, recipient of the Medal of Honor
Fictional
- Martin Lukes, fictional character featured in Financial Times column
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