Lymphocyte expansion molecule (LEXM) is a protein discovered in 2015, found to be involved in immune responses (in mice) to some cancers and viruses. The protein was initially found to be responsible for an increased production of T cells in mice. The original paper has since been retracted upon recommendation of Imperial College's investigators due to concerns about duplication of data. The protein may be relevant to humans and could be a target for drug discovery.
Scientists at Imperial College are developing a gene therapy based on this protein.
References
- ^ Knapton, Sarah (16 April 2015). "Scientists find key to 'turbo-charging' immune system to kill all cancers". telegraph.co.uk. The Telegraph. Retrieved 8 September 2017.
- Okoye at al. (April 2015). "The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration". Science. 348 (6238): 995–1001. doi:10.1126/science.aaa7516. hdl:10044/1/34339. PMID 25883318. (Retracted, see doi:10.1126/science.aal5242, PMID 27980177, Retraction Watch. If this is an intentional citation to a retracted paper, please replace
{{retracted|...}}with{{retracted|...|intentional=yes}}.) - Retraction. 2016
- Previously Unknown Protein Boosts Immunity to Cancer and Viruses. 2015
- 'Game-changing' new way to fight cancer discovered
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