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MFSD1

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Protein-coding gene in the species Homo sapiens
MFSD1
Identifiers
AliasesMFSD1, SMAP4, major facilitator superfamily domain containing 1, Minerva
External IDsMGI: 1914118; HomoloGene: 11228; GeneCards: MFSD1; OMA:MFSD1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for MFSD1Genomic location for MFSD1
Band3q25.32Start158,732,198 bp
End158,829,719 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for MFSD1Genomic location for MFSD1
Band3|3 E1Start67,490,074 bp
End67,511,570 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • trabecular bone

  • palpebral conjunctiva

  • visceral pleura

  • epithelium of nasopharynx

  • parietal pleura

  • gums

  • skin of hip

  • parotid gland

  • gingival epithelium
Top expressed in
  • stroma of bone marrow

  • right kidney

  • yolk sac

  • human kidney

  • proximal tubule

  • olfactory epithelium

  • primitive streak

  • lactiferous gland

  • submandibular gland

  • calvaria
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

64747

66868

Ensembl

ENSG00000118855

ENSMUSG00000027775

UniProt

Q9H3U5

Q9DC37

RefSeq (mRNA)

NM_001167903
NM_001289406
NM_001289407
NM_022736

NM_025813

RefSeq (protein)

NP_001161375
NP_001276335
NP_001276336
NP_073573

NP_080089

Location (UCSC)Chr 3: 158.73 – 158.83 MbChr 3: 67.49 – 67.51 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Major facilitator superfamily domain containing 1 (MFSD1, SMAP) is a protein belonging to the MFS Pfam clan. It is an Atypical solute carrier.

It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified in neuronal plasma membranes and lysosomes.

HGNC:25874

MFSD1 belongs to AMTF6.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000118855 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027775 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  6. ^ Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.
  7. Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A (June 2013). "An extended proteome map of the lysosomal membrane reveals novel potential transporters". Molecular & Cellular Proteomics. 12 (6): 1572–88. doi:10.1074/mcp.M112.021980. PMC 3675815. PMID 23436907.
  8. Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011). "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways". Human Molecular Genetics. 20 (19): 3852–66. doi:10.1093/hmg/ddr306. PMID 21752829.
  9. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
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