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The first regular-season games to be played in Mexico City took place during the 2023 season on April 29–30, between the Padres and San Francisco Giants, as part of MLB World Tour (MLB games played outside of the United States and Canada). The Padres, the designated home team, won both games, by scores of 16–11 and 6–4. The crowd was heavily biased towards the Padres, who are based very close to the Mexican border, and attracted fans from the U.S. and from across Mexico. Due to the high altitude and hitter-friendly dimensions of the stadium, the first game included 11 home runs from 10 different players, tying an MLB record. On the Wednesday after the trip, Giants pitcher Logan Webb told reporters that he thought most of the Giants team returned from Mexico City with digestive ailments.
For the 2024 season, MLB announced two games between the Houston Astros and Colorado Rockies, scheduled for April 27–28. Television coverage by Imagen Televisión and ESPN was planned for both games although only the first was aired for free in Mexico and only the latter was aired nationally in the United States. The Astros won both games, by scores of 12–4 and 8–2.