Manganelli is an Italian surname. Notable people with the surname include:
- Antonio Manganelli (1950–2013), Italian police chief
- Francesco Manganelli (1940–2022), Italian writer and politician
- Giorgio Manganelli (1922–1990), Italian journalist, writer, translator and literary critic
- Pietro Manganelli, (born 1993) Italian footballer
- Roger Manganelli (born 1974), American musician
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