Mannan-binding lectin-associated serine protease-2

Mannan-binding lectin-associated serine protease-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme. This enzyme catalyses the following chemical reaction

Selective cleavage after Arg in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)

This mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine.

References

Matsushita M, Fujita T (December 1992). "Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease". The Journal of Experimental Medicine. 176 (6): 1497–502. doi:10.1084/jem.176.6.1497. PMC 2119445. PMID 1460414.
Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC (April 1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature. 386 (6624): 506–10. doi:10.1038/386506a0. PMID 9087411.
Rossi V, Cseh S, Bally I, Thielens NM, Jensenius JC, Arlaud GJ (November 2001). "Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2". The Journal of Biological Chemistry. 276 (44): 40880–7. doi:10.1074/jbc.M105934200. PMID 11527969.
Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, Gráf L, Laich A, Moffatt BE, Schwaeble W, Sim RB, Závodszky P (February 2003). "Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments". Journal of Immunology. 170 (3): 1374–82. doi:10.4049/jimmunol.170.3.1374. PMID 12538697.
Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, Náray-Szabó G, Závodszky P (October 2004). "The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions". Journal of Molecular Biology. 342 (5): 1533–46. doi:10.1016/j.jmb.2004.07.014. PMID 15364579.
Chen CB, Wallis R (June 2004). "Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases". The Journal of Biological Chemistry. 279 (25): 26058–65. doi:10.1074/jbc.M401318200. PMID 15060079.
Teillet F, Dublet B, Andrieu JP, Gaboriaud C, Arlaud GJ, Thielens NM (March 2005). "The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases". Journal of Immunology. 174 (5): 2870–7. doi:10.4049/jimmunol.174.5.2870. PMID 15728497.

External links

Mannan-binding+lectin-associated+serine+protease-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 3.4.21