Masire may refer to the following people
- Given name
- Masire Kamara, Sierra Leone celebrity and tea seller
- Surname
- Gladys Olebile Masire (1932–2013), teacher and political figure from Botswana, wife of Quett Masire
- Quett Masire (1925–2017), second President of Botswana
- Tebogo Masire, commander of the Botswana Defence Force
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