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MT2A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1MHU, 2MHU
Identifiers
Aliases	MT2A, MT2, Metallothionein 2A, MT-II, MT-2
External IDs	OMIM: 156360; HomoloGene: 136536; GeneCards: MT2A; OMA:MT2A - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q13 Start 56,608,584 bp End 56,609,497 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium right lobe of liver olfactory bulb mucosa of transverse colon left uterine tube external globus pallidus cartilage tissue right lobe of thyroid gland upper lobe of left lung Region I of hippocampus proper n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding zinc ion binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol nucleus Biological process response to metal ion cellular response to interleukin-3 cellular response to erythropoietin negative regulation of growth cellular response to zinc ion interferon-gamma-mediated signaling pathway cellular copper ion homeostasis cellular zinc ion homeostasis detoxification of copper ion cellular response to cadmium ion cellular response to copper ion nitric oxide mediated signal transduction response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4502 n/a Ensembl ENSG00000125148 n/a UniProt P02795 n/a RefSeq (mRNA) NM_005953 n/a RefSeq (protein) NP_005944 n/a Location (UCSC) Chr 16: 56.61 – 56.61 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.

The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases.

Interactions

Metallothionein 2A has been shown to interact with protein kinase D1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000125148 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Karin M, Richards RI (Dec 1982). "Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene". Nature. 299 (5886): 797–802. Bibcode:1982Natur.299..797K. doi:10.1038/299797a0. PMID 7133118. S2CID 4332683.
4. "Entrez Gene: MT2A metallothionein 2A".
5. Sekovanić A, Jurasović J, Piasek M (2020). "Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans". Arhiv Za Higijenu Rada I Toksikologiju. 71 (1): 27–47. doi:10.2478/aiht-2020-71-3349. PMC 7837243. PMID 32597135.
6. Rao, Prema S; Jaggi Meena; Smith David J; Hemstreet George P; Balaji K C (Oct 2003). "Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer". Biochem. Biophys. Res. Commun. 310 (3). United States: 1032–8. doi:10.1016/j.bbrc.2003.09.118. ISSN 0006-291X. PMID 14550308.

Further reading

• Kissling MM, Kägi HR (1977). "Primary structure of human hepatic metallothionein". FEBS Lett. 82 (2): 247–50. Bibcode:1977FEBSL..82..247K. doi:10.1016/0014-5793(77)80594-2. PMID 913597. S2CID 46396323.
• Yamazaki S, Nakanishi M, Hamamoto T, et al. (1993). "Expression of human metallothionein-II fusion protein in Escherichia coli". Biochem. Int. 28 (3): 451–60. PMID 1339282.
• Messerle BA, Schäffer A, Vasák M, et al. (1992). "Comparison of the solution conformations of human -metallothionein-2 and -metallothionein-2 using nuclear magnetic resonance spectroscopy". J. Mol. Biol. 225 (2): 433–43. doi:10.1016/0022-2836(92)90930-I. PMID 1593628.
• Zafarullah M, Martel-Pelletier J, Cloutier JM, et al. (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte". FEBS Lett. 306 (2–3): 169–72. Bibcode:1992FEBSL.306..169Z. doi:10.1016/0014-5793(92)80992-P. PMID 1633872. S2CID 43460076.
• Messerle BA, Schäffer A, Vasák M, et al. (1990). "Three-dimensional structure of human metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy". J. Mol. Biol. 214 (3): 765–79. doi:10.1016/0022-2836(90)90291-S. PMID 2388267.
• Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW (1989). "Changes in brain gene expression shared by scrapie and Alzheimer disease". Proc. Natl. Acad. Sci. U.S.A. 86 (18): 7260–4. Bibcode:1989PNAS...86.7260D. doi:10.1073/pnas.86.18.7260. PMC 298037. PMID 2780570.
• Karin M, Haslinger A, Heguy A, et al. (1987). "Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity". Mol. Cell. Biol. 7 (2): 606–13. doi:10.1128/mcb.7.2.606. PMC 365115. PMID 3821726.
• Karin M, Haslinger A, Holtgreve H, et al. (1984). "Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene". Nature. 308 (5959): 513–9. Bibcode:1984Natur.308..513K. doi:10.1038/308513a0. PMID 6323998. S2CID 4357363.
• Schmidt CJ, Hamer DH, McBride OW (1984). "Chromosomal location of human metallothionein genes: implications for Menkes' disease". Science. 224 (4653): 1104–6. Bibcode:1984Sci...224.1104S. doi:10.1126/science.6719135. PMID 6719135.
• Karin M, Richards RI (1982). "Human metallothionein genes: molecular cloning and sequence analysis of the mRNA". Nucleic Acids Res. 10 (10): 3165–73. doi:10.1093/nar/10.10.3165. PMC 320698. PMID 6896577.
• Lambert E, Kille P, Swaminathan R (1996). "Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes". FEBS Lett. 389 (2): 210–2. Bibcode:1996FEBSL.389..210L. doi:10.1016/0014-5793(96)00587-X. PMID 8766831. S2CID 8195335.
• Woo ES, Dellapiazza D, Wang AS, Lazo JS (1999). "Energy-dependent nuclear binding dictates metallothionein localization". J. Cell. Physiol. 182 (1): 69–76. doi:10.1002/(SICI)1097-4652(200001)182:1<69::AID-JCP8>3.0.CO;2-9. PMID 10567918. S2CID 31787611.
• Jiang LJ, Vasák M, Vallee BL, Maret W (2000). "Zinc transfer potentials of the alpha - and beta-clusters of metallothionein are affected by domain interactions in the whole molecule". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2503–8. Bibcode:2000PNAS...97.2503J. doi:10.1073/pnas.97.6.2503. PMC 15958. PMID 10716985.
• Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". Prostate. 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. S2CID 8768274.
• Ebert MP, Günther T, Hoffmann J, et al. (2000). "Expression of metallothionein II in intestinal metaplasia, dysplasia, and gastric cancer". Cancer Res. 60 (7): 1995–2001. PMID 10766190.
• Toyama M, Yamashita M, Hirayama N, Murooka Y (2003). "Interactions of arsenic with human metallothionein-2". J. Biochem. 132 (2): 217–21. doi:10.1093/oxfordjournals.jbchem.a003213. PMID 12153718.
• Sun X, Kang YJ (2002). "Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity". Exp. Biol. Med. (Maywood). 227 (8): 652–7. doi:10.1177/153537020222700815. PMID 12192109. S2CID 45099558.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.

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