Methylenediurea deaminase

Identifiers

Databases

PDB structures

Methylenediurea deaminase (EC 3.5.3.21, methylenediurease) is an enzyme with systematic name methylenediurea aminohydrolase found in Brucella anthropi, a bacterium. This enzyme catalyses the following chemical reaction:

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N-(hydroxymethyl)urea + 2 NH₃ + CO₂ (overall reaction)

(1a) methylenediurea + H₂O

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N-(carboxyaminomethyl)urea + NH₃

(1b) N-(carboxyaminomethyl)urea

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N-(aminomethyl)urea + CO₂ (spontaneous)

(1c) N-(aminomethyl)urea + H₂O

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N-(hydroxymethyl)urea + NH₃ (spontaneous)

Methylenediurea is hydrolysed and decarboxylated to give an aminated methylurea.

References

Jahns T, Schepp R, Kaltwasser H (1997). "Purification and characterisation of an enzyme from a strain of Ochrobactrum anthroπ that degrades condensation products of urea and formaldehyde (ureaform)". Canadian Journal of Microbiology. 43: 1111–1117. doi:10.1139/m97-159.

v t e Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aminoacylase ACY1 Aspartoacylase(ACY2) ACY3 Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin
3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase Dihydroorotase
3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase
3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase
3.5.5: Nitriles/ Aminohydrolases	Nitrilase
3.5.99: Other	Riboflavinase Thiaminase II

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)