Mezgebu is a surname. Notable people with the surname include:
- Mezgebu Muluneh Genanaw~መዝገቡ ሙሉነህ ገናናው (መዝገበ-አብ/Mezgebe-ab As Well)
(Born In June 1991 G.C) Gemini ,
- Ethiopian Prominent Journalist In The National Broadcasting Corporation, And Known as a Content & Gramatical Editor Of Several Psycholgical, Fictitious, Scientific And Poetic Books printed in Amharic and English Languages
- Assefa Mezgebu (born 1978), Ethiopian long-distance runner
- Ayele Mezgebu (born 1973), Ethiopian long-distance runner
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