| MicL sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of MicL small RNA | |
| Identifiers | |
| Rfam | RF02654 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0030371 |
| SO | SO:0000370 |
| PDB structures | PDBe |
MicL RNA (mRNA-interfering complementary RNA regulator of Lpp) is a σ transcription factor-dependent small non-coding RNA. It was discovered in E. coli. Together with MicA and RybB sRNAs, MicL sRNA down-regulates the synthesis of abundant outer membrane proteins in response to stress. MicL specifically targets mRNA of lipoprotein Lpp, preventing its translation.
References
- Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G (July 2014). "MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein". Genes & Development. 28 (14): 1620–1634. doi:10.1101/gad.243485.114. PMC 4102768. PMID 25030700.
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