Millspaugh is a surname. Notable people with the surname include:
- Arthur Millspaugh (1883-1955), adviser at the U.S. State Department's Office of the Foreign Trade
- Charles Frederick Millspaugh (1854-1923), American botanist
- Frank Millspaugh (disambiguation):
- Frank C. Millspaugh (1872-1947), U.S. Representative from Missouri
- Frank Rosebrook Millspaugh (1848–1916), bishop of Kansas
See also
- Millspaugh, California, unincorporated community in Inyo County, California
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